The study's main goal was to analyze the CSFs of PPPs as an alternative social infrastructure financing strategy in Lusaka, Zambia's health sector. Precisely, the study aimed to examine the factors influencing implementation of PPPs in the Health Sector in Lusaka, Zambia. The study adopted the pragmatism research philosophy, mixed-method research approach and survey research strategy. Purposive and stratified random sampling techniques were employed. Data were collected using questionnaires, interviews and document review and analysed using descriptive, ANOVA, factor, content and regression analyses. The study found that the main CSFs for implementation in the health sector include socio-cultural, political, legal, economic, environmental and technical factors. However, socio-cultural, political, legal, economic and technical factors were found to be significant CSFs for PPP implementation and these formed the proposed framework for implementation of PPPs for the health sector in Lusaka, Zambia. The study therefore concluded that there are several factors that influence successful actualisation and implementation of PPP projects in the health sector in Lusaka, Zambia where the major ones include socio-cultural, political, legal, economic and technical factors. The study recommended the government of Zambia to take into account establishing strong policy frameworks and reliable governance mechanisms to ensure the successful implementation of PPPs in the country's health sector. The study made significant contributions to theory, policy and practice.